Skip to main content
Schedule a Visit Apply Now
Yun Ho Kim, Ph.D

Yun Ho Kim, Ph.D

Professor of Bioorganic Chemistry

Dr. Yun-Ho Kim is a professor of chemistry at The University of West Alabama. He joined UWA in the Fall of 2006 and his main areas of teaching are Organic Chemistry and Biochemistry. Dr.Kim's research area is Organic/Bio-organic/Protein Chemistry and one of his main research goals is to explore and understand the underlying physical and chemical principles that affect a protein structure as well as how these factors contribute to the overall stability of the structure once it is formed. In the longer term, this knowledge will be applied to practical purposes such as increasing protein stability, designing protein structures, and bioengineering toward drug synthesis. In order to accomplish these objectives, the combined techniques of molecular biology, biophysics, organic and peptide chemistry are being employed. Dr. Kim’s main interest in this research is chemical modification of proteins in the following areas: 1) methionine and/or cysteine oxidation/ reduction, an apparently important process in human disease and aging and 2) cross linking the reaction of the protein at introduced cysteine residues. Staphylococcal nuclease is a model protein in his laboratory because the protein only contains 4 methionine residues and no cystein residue that could act as a control factor. In addition, there is one tryptophan residue that could be utilized as a fluorescence probe for protein folding and unfolding studies.

Yun Ho Kim, Ph.D


Another research area is to study the naturally occurring potential anti-aging/anti-cancer drugs. Many different types of natural antioxidants will be tested for oxidation inhibition study. Artemisia princeps is particularly interesting because many of its extracts have been shown to be potential treatments for inflammation, cancer, and other disorders. Artemisinin (anti-malaria), flavonoid (anti-cancer), eupatiline (chemopreventive and cytotoxin) and many other components are the extracts from the Artemisia princeps. A third research area is to extract the essential oils from the natural plants to test their biological activities. N-(n-anisyl)ethyl-N-Methylcinnamamide, a novel product was successively isolated and purified from the Zanthoxylum clava-herculis tree in the  Black Belt region of Alabama and it will be further screened for its biological activities and the mlti-step synthesis will be employed to yield its derivatives for targeting the possible application to generate the medical drug.
Dr. Kim is currently advisor of SAACS (Student affiliated American Chemical Society) and Pre-Med, Pre-Pharm, and Pre-Dental in Physical Science department. He is also heavily involved in UWA's Exchange Program abroad through the International Programs Office. He established a dual degree program with the Harrison School of Pharmacy at Auburn University at The University of West Alabama (UWA). In addition, he also established an exchange program with Dankook University in Korea at UWA.

http://facstaff.uwa.edu/ykim/

Education

  • Postdoc- Protein Biochemistry University of Iowa Department of Biochemistry 2004
  • Ph.D- Bioorganic Chemistry University of Arkansas Department of Chemistry & Biochemistry 2003
  • MS- Organometallic Chemistry University of Connecticut Dept. of Chemistry & Biochemistry 1995
  • MS- Organic Chemistry Indiana University of Pennsylvania Department of Chemistry 1992
  • BS- Chemistry Yonsei University Department of Chemistry 1987
  • Recent Publications

  • Kim Y.H., Gogerty D.S., Plapp B.P., Substitutions of a Buried Glutamate Residue Hinder the Conformational Change in Horse Liver Alcohol Dehydrogenase and Yield a Surprising Complex with Endogenous 3’-Dephosphocoenzyme A. ABB (Archives of Biochemistry and Publication 2018
  • Kim Y.H., Stites WE., Excluded volume effects upon protein stability in covalently crosslinked proteins with variable linker lengths. Biochemistry, 2008; 47 (33), 8804–8814, 10.1021/bi800297j Publication 2008
  • Kim Y.H., Stites WE. Oxidation of buried cysteines is slow and an insignificant factor in the structural destabilization of staphylococcal nuclease caused by H2O2 exposure. Amino Acids 2004; 27; 175-181. Publication 2004
  • Kim Y.H., Berry AH, Spencer DS, Stites WE. Comparing the effect on protein stability of methionine oxidation versus mutagenesis: Steps toward engineering oxidative resistance in proteins. Protein Eng 2001; 14: 343-347. Publication 2001
  • Kim Y.H., Moon, K.Y., New compound, N-(n-anisyl)ethyl-N-Methylcinnamamide extracted from Zanthoxylum clava-herculis tree bark at the ACS (American National Society Conference at New Orleans, LA. Mar. 18-22, 2018 Presentation 2018
  • Kim Y.H., Smith K.L., Moore C.M., A Study of Ginkgo biloba Sarcotesta, URS at UWA, Livingston, AL, Mar. 08, 2016 Presentation 2016
  • Kim Y.H., Moon, K.Y., Lee, K., Synthesis of Tooth Anesthetic: (E)-N-(4-methoxyphenethyl)-N-methylcinnamamide, at the Twelfth International Symposium on Recent Advances in Environmental Health Research, Jackson State University, MS, Sept 15, 2015 Presentation 2015
  • Kim Y.H., Thinking outside the Box: The Effect of an informal setting on student, AAS (Alabama Academy of Sciences) meeting at UWA, AL, March 2015 Presentation 2015
  • Kim Y.H., Riley Z.L., A study of Zanthoxylum clava-herculis L. in the Black Belt: Essential Oil Extraction, AAS (Alabama Academy of Sciences) meeting at UWA, AL, March 2015 Presentation 2015
  • Kim Y.H., Hassell J.L, Schermer S.R., Inhibition Studies of Anti-oxidants on Staphylococcal Nuclease Oxidation. Alabama Academy of Science (86th annual meeting) at UWA, Livingston, AL, March 2009 Presentation 2009
  • Kim Y.H., Gogerty DS, Plapp BV., Mutating the buried Glutamate-267 in Horse Liver Alcohol Dehydrogenase activities the enzyme and locks it in the open conformation. ACS National meeting, Biological Chemistry Division, New Orleans, Louisiana, April 2008 Presentation 2008
  • Kim Y.H., Stites WE., Excluded volume effects upon protein stability in covalently crosslinked proteins with variable linker lengths. ACS National meeting, Biological Chemistry Division, New Orleans, Louisiana, April 2008 Presentation 2008
  • Kim Y.H., Gogerty DS, Plapp BV., Mutating the buried Glutamate-267 in Horse Liver Alcohol Dehydrogenase activities the enzyme and locks it in the open conformation. ASBMB, Washington D.C. 2007 Presentation 2007
  • Kim Y.H., Stites WE., Altering the sensitivity of protein to oxidative damage. Biophysical Society Annual Meeting, Kansas City, MO, Febuary 1998. Presentation 1998
  • Kim Y.H., Wood J.T., A Study of the copper induced cleavage of 2-phenyl-4-methyl-1,3-oxathiolan-5-one. Northeast Regional of the American Chemical Society, Syracuse, NY, June 1992. Presentation 1992